diff -ruN protobuf-21.8/python/google/protobuf/pyext/descriptor.cc protobuf-21.8-patch/python/google/protobuf/pyext/descriptor.cc
--- protobuf-21.8/python/google/protobuf/pyext/descriptor.cc	2022-10-18 17:45:18.000000000 +0200
+++ protobuf-21.8-patch/python/google/protobuf/pyext/descriptor.cc	2022-10-26 21:57:26.217437077 +0200
@@ -58,6 +58,37 @@
               : 0)                                               \
        : PyBytes_AsStringAndSize(ob, (charpp), (sizep)))
 
+#if PY_VERSION_HEX < 0x030900B1 && !defined(PYPY_VERSION)
+static PyCodeObject* PyFrame_GetCode(PyFrameObject *frame)
+{
+    Py_INCREF(frame->f_code);
+    return frame->f_code;
+}
+
+static PyFrameObject* PyFrame_GetBack(PyFrameObject *frame)
+{
+    Py_XINCREF(frame->f_back);
+    return frame->f_back;
+}
+#endif
+
+#if PY_VERSION_HEX < 0x030B00A7 && !defined(PYPY_VERSION)
+static PyObject* PyFrame_GetLocals(PyFrameObject *frame)
+{
+    if (PyFrame_FastToLocalsWithError(frame) < 0) {
+        return NULL;
+    }
+    Py_INCREF(frame->f_locals);
+    return frame->f_locals;
+}
+
+static PyObject* PyFrame_GetGlobals(PyFrameObject *frame)
+{
+    Py_INCREF(frame->f_globals);
+    return frame->f_globals;
+}
+#endif
+
 namespace google {
 namespace protobuf {
 namespace python {
@@ -92,52 +123,72 @@
 // TODO(amauryfa): Change the proto2 compiler to remove the assignments, and
 // remove this hack.
 bool _CalledFromGeneratedFile(int stacklevel) {
-#ifndef PYPY_VERSION
+#ifdef PYPY_VERSION
+  return true;
+#else
+  bool result = false;
   // This check is not critical and is somewhat difficult to implement correctly
   // in PyPy.
   PyFrameObject* frame = PyEval_GetFrame();
+  PyCodeObject* frame_code = nullptr;
+  PyObject* frame_globals = nullptr;
+  PyObject* frame_locals = nullptr;
+
   if (frame == nullptr) {
-    return false;
+    goto exit;
   }
+  Py_INCREF(frame);
   while (stacklevel-- > 0) {
-    frame = frame->f_back;
+    PyFrameObject* next_frame = PyFrame_GetBack(frame);
+    Py_DECREF(frame);
+    frame = next_frame;
     if (frame == nullptr) {
-      return false;
+      goto exit;
     }
   }
 
-  if (frame->f_code->co_filename == nullptr) {
-    return false;
+  frame_code = PyFrame_GetCode(frame);
+  if (frame_code->co_filename == nullptr) {
+    goto exit;
   }
   char* filename;
   Py_ssize_t filename_size;
-  if (PyString_AsStringAndSize(frame->f_code->co_filename,
+  if (PyString_AsStringAndSize(frame_code->co_filename,
                                &filename, &filename_size) < 0) {
     // filename is not a string.
     PyErr_Clear();
-    return false;
+    goto exit;
   }
   if ((filename_size < 3) ||
       (strcmp(&filename[filename_size - 3], ".py") != 0)) {
     // Cython's stack does not have .py file name and is not at global module
     // scope.
-    return true;
+    result = true;
+    goto exit;
   }
   if (filename_size < 7) {
     // filename is too short.
-    return false;
+    goto exit;
   }
   if (strcmp(&filename[filename_size - 7], "_pb2.py") != 0) {
     // Filename is not ending with _pb2.
-    return false;
+    goto exit;
   }
 
-  if (frame->f_globals != frame->f_locals) {
+  frame_globals = PyFrame_GetGlobals(frame);
+  frame_locals = PyFrame_GetLocals(frame);
+  if (frame_globals != frame_locals) {
     // Not at global module scope
-    return false;
+    goto exit;
   }
+  result = true;
+exit:
+  Py_XDECREF(frame_globals);
+  Py_XDECREF(frame_locals);
+  Py_XDECREF(frame_code);
+  Py_XDECREF(frame);
+  return result;
 #endif
-  return true;
 }
 
 // If the calling code is not a _pb2.py file, raise AttributeError.