DUfBddlZddlZddlZ d dZd dZ d d ZdS)N TFc|j}|jdz}||z }|r|djnt j|t} ||d|dz |dz dzk} |r!| | d} | dj|z } | dj|z } |r | djn | dj} t j|}t j|}td |D]}||kr | |z| k| |z|kz| d kz}|t j | ||z| || z }t j|t}|d kr|| z}n ||dxx| d| zcc<|| z}||dxxd||dz z cc<t j|}t j|}td |D]}||kr | | |z k| |kz| |z d kz}|t j | || || z }t j|t}|| z}|d kr|| z}n|d| xx| |dzcc<|d|r| ndxxd|d|r| ndz z cc<tj 5tj d |}|}|r5||zd z }t j ||z ||z dz||z dzzz|z }n ||z ||zz }dddn #1swxYwY|S) Nweight)dtypebin2_idbin1_idrbalancedcountr) minlengthignore@)indexminmaxisnullvaluesnpzerosboolrangebincountwarningscatch_warnings simplefiltersign)pixelsbinswindow ignore_diagsr signed_chi2 lo_bin_id hi_bin_idN bad_bin_mask diag_pixelsijvalsum_pixels_left n_pixels_lefti_shiftmaskloc_bad_bin_masksum_pixels_rightn_pixels_rightj_shiftabescores Y/var/www/html/software/conda/lib/python3.11/site-packages/cooltools/api/directionality.py _dirscorer8s?   I   1$IIA+3OX&&$8O8O8O *VI->>6A:QRBRRSKE!;z#:#A#A#C#C"CD I% 1AI% 1A,4 U+j ! ( (+g:N:UChqkkOHQKKMF## B B \ ! ! G q Q[1_5a@2;qw'8#d)qQQQQ8AT222 a<<  ,   WXX & & &,yy*A A & & &  , ghh1'7'A#AAx{{Xa[[NF##   \ ! ! Q[ QU+q7{a/?@BK$TaHHHH8AT222L( a<<  ,   YwhY ' ' '<+A A ' ' '8g77((48999  !B$AWHHT!BC C 9999  " " & &h'''    &Q# AGAENNq1ula!e\&ABQFEEUq1u%E & & & & & & & & & & & & & & & Ls#AM  MMc $|jd}tj|}td|D]}t d||z }t ||zdz|}tj||||ftj||||dzf} }|r:| |zdz } | r/tj|| z | | z dz|| z dzzz| z ||<|| z | |zz ||<tj|ddk} tj|| <|S)Nrrrr)axis) shaperrrrrnansumrnan) Ar r"r%dir(lohir4r3r5r.s r7_dirscore_denserBLs*  A !B 1a[[ & & AJ   !f*!1 % %y1ad7$$bi!R!a%Z-0@&A&A1  &Q# A KA1q5Q,!a%A*EFJ1Uq1u%BqEE 9QQ   1 $DvBtH I順rc ~||j}|jd}||n5||jddzd}||z}||zdkr#t d||g}|D]!} || } | d| | } tj | d j } tj | } td|D]U}|dkr| | z} | tjdg|z| d| fz} | tj| |ddg|zfz} V| gd }| |d <t#j5t#jd t(t+| | ||}tj|| <tj|tj|<||d|<t+| | ||d}tj|| <tj|tj|<||d|<dddn #1swxYwY||#t3j|}|S)a Calculate the diamond insulation scores and call insulating boundaries. Parameters ---------- clr : cooler.Cooler A cooler with balanced Hi-C data. window_bp : int The size of the sliding diamond window used to calculate the insulation score. min_dist_bad_bin : int The minimal allowed distance to a bad bin. Do not calculate insulation scores for bins having a bad bin closer than this distance. ignore_diags : int The number of diagonals to ignore. If None, equals the number of diagonals ignored during IC balancing. Returns ------- ins_table : pandas.DataFrame A table containing the insulation scores of the genomic bins and the insulating boundary strengths. Nzbin-size/z /bins/weightr!rz>@@ &6 "#  $ & & O O  !(N ; ; ;!j<I+-&I& '13Ir{9--- .ENI/66yAA B!") I+-&I& '13Ir{9--- .ENI/66yAA B% O O O O O O O O O O O O O O O(  **** *++I s'CJJ J )rrTF)rF)rDrrNN)rnumpyrpandasr]r8rBrmrCr7rqsINDDDDN(  YYYYYYrC